January - 2012
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Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical PatientsNew England Journal of Medicine, 2011, 365:2463-2472 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
January |
Previous Comments
| That's a bugger. | |
| Darren Cable-29 Jan, 2012 04:28:03 PM | |
| This seems like a very well run trial, placebo controlled, well blinded. Doesn't seem particularly applicable to practice in more resource-rich settings though. What do we get from this? The risk of fatal PE, even in at risk groups, is remarkably low, whether you give prophylaxis or not. Interesting. Also, the risk of haemorrhagic complications in this group is no higher than background. Interesting. Is it enough to change practice (i.e. not give clexane to this higher risk group of medical patients)? I wouldn't think so. | |
| Jo Butler-13 Mar, 2012 03:07:27 PM | |
Comment
Hmmm.
This very large, randomised, placebo controlled trial, conducted in a selected group of at-risk medical patients, found no difference in outcome when clexane was added to conventional mechanical DVT prophylaxis.
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